![]() The group assessment will be triggering the students' teamwork and critical thinking. The assessment can be done individually and in a group.Before you do an assessment, make sure that the children are already practising enough.First, we need to remember that different types of sight words also need a different assessment.In order to know whether sight word learning has been effective or not, we can determine through assessment. Fifth, make into daily activities with the read-and-play sight word activities.Fourth, try to group the sight words into some categories.Third, it is good to enhance the children's multi-sensories while learning sight words.Second, you can start with reading a children's book by a read-aloud method and make it into a more interactive activity.Learning sight words at a young age can improve children's literacy skills more quickly. First, teachers and parents need to get the children to know about sight worlds as early as possible.Here are some ways how teachers and parents can teach sight words to young learners to accelerate their vocabulary development. The Top 150 Written Words are the most recent word list that consists of 150 words we usually find in English text.Ĭhildren can learn about sight words both in school and at home.Fry Sight Words are a more modern word list that is based on familiar words to show up in children's books.Dolch Sight Words is a list of sight words found by William Dolch, which consists of frequently used words in a children's book.There are other types of sight words we can find, which are D olch Sight Words, Fry Sight Words, and Top 150 Words. These two types of sight words are the most common type mentioned by the experts. Non-phonetic words are words that cannot be decoded phonetically, such as buy, talk, and come. ![]() Frequently used words are words that constantly appear in the text, such as it, can, will, the, and more.Mainly, sight words are divided into two categories, frequently used words and non-phonetic words. This process unavoidably will increase the students' competence in reading comprehension. Mastering sight words will activate the learners' observation of the meaning and pronunciation. She said, by mastering sight word recognition, students will enhance their reading skills. Some studies stated that most readers need around one to four-word exposure, to store the words in their long-term memory.ĭini Amalia stated in her paper the importance of sight words for students. While we teach the young learners about sight words, the students will store the vocabulary in their long-term memory. You can use many kinds of activities, so the students will not feel bored. Last, make sure to continue reinforcing the target sight words with repeated exposure.Next, the teacher can use a flashcard from our Sight Words Worksheets for 5th Grade to engage in a flashcard activity in the classroom.First, the teacher shall start with sound-letter mapping.Lyon also recommends using Three-Part Strategy to teach children about sight words. These are the words that will become sight words. Some study experts refer to the word that regularly appears in students' reads as a high-frequency word. This will lead them to understand the topic better. The result is, the students can read smoothly without any struggles. When the learners become mundane to these words, they no longer need to stop reading and trying to guess the word. This is the best method that can complement phonics learning. Cheryl Lyon explains that the sight words are words that students are supposed to recognize immediately. ![]() Prepare your children to be an adequate readers, with these 19 Sight Words Worksheets for 5th Grade! What are Sight Words?īefore we dive in deeper, let's get to know what sight words are first. So, if you're a 5th grade teacher or a parent looking for effective resources to reinforce sight word learning, our sight words worksheets are the perfect solution for you. Finally, it will have a positive impact on children's communication and reading skills. Understanding these words can increase children's vocabulary. ![]() With a variety of engaging exercises, these worksheets offer plenty of opportunities for students to practice and master these crucial words. These worksheets are carefully crafted to help young learners build and strengthen their reading and writing skills by focusing on essential sight words. Introducing our comprehensive collection of sight words worksheets designed specifically for 5th grade students. ![]()
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![]() The amperage hour (Ah) of a battery determines how much power juice it contains to run your tool, like the fuel tank of your car engine. But if you use a 40V battery with your 20V device, it can damage the internal components of your tool and risk short circuit as well. Warning: If you use a 20V battery with a 40V tool, it can minimize the performance and speed of your device. If your device is 20V, it’s better to use 20V instead of 40V and vice versa. Therefore, to get optimal performance from your power tool, your battery voltage should be compatible with your specific power tool. The voltage determines how powerful your tool will be. The voltage of your battery works like a power push that fuels your battery. So, if you want to buzz your device with outstanding energy to perform well, use the Bauer compact powerhouses wisely. This appropriateness is called compatibility. This harmony generates the appropriate energy to power up your tool efficiently. It consists of a unique mechanism in which all the internal components, cells, connectors, and chemicals are interconnected and function harmoniously. So, is the rule for Bauer batteries also, whether it falls in any category (Ni-Cd, Ni-mh, Li-ion). ![]() The mechanism of every battery brand is different from each other and specific. The Lithium-ion battery is inappropriate for a Ni-Cd tool and vice versa. To choose a compatible battery for your particular off-brand tool, check out these chemical properties of mortars. And Lithium-Ion (Li-ion) (Innovative tech).Nickel-Metal Hydride (Ni-MH), (Older version).Nickel-cadmium (Ni-Cd), (Older version).It’s like solving a puzzle that demands the correct shape, size, and angle to complete the picture.īauer batteries have different variations: In the power heaven, finding the match made is pivotal. No matter whether you are tech-savvy or a common man without any tech background, you can analyze this factor quickly. The accurate connection of metal connectors leaves no room for energy leaks, and your battery efficiently provides power juice to your power-hungry tool. For proper compatibility, the battery should be fixed properly in the device without waggling. The latches and connectors are scientifically structured in a specific way that fits your tool’s slot easily and locks well with a click. Before using your Bauer battery with any tool, check the latches and connectors of your battery. The first and foremost is its design and structure. Let’s analyze these factors to determine the best compatibility: 1- Design & Structure These structural, mechanical, and chemical factors decide its best compatibility with different off-brand tools. It involves many factors regarding Bauer battery compatibility with other brand power tools. ![]() Conclusion Explanation of Battery Compatibility.3- Harbor Freight Bauer battery compatibility?.2- What batteries are compatible with Bauer?. ![]() 1- Do Dewalt batteries fit Bauer tools?.Bauer – Other Brand Compatibility Chart. ![]() ![]() ![]() Your STYLE…your call.Īt the bottom of the template, I give you ideas of theme days.īelow those examples is the space to fill in your own choices. While you could fill up the whole month, you can also do it one week at a time. You’ll have permission to not cook those nights…and you it’s not as overwhelming as a whole month of boxes to fill up! Start by crossing off the days you won’t be cooking. (Not to worry, I give examples on the template too!) This is a great thing to ask ChatGPT to get your wheels turning on theme night options. Then put my menu on the fridge to refer during the week.įree menu template option #2: Monthly Themed Dinnersīroken record alert…using templates for meal planning will save you TONS of time meal planning.Īnother great way to give yourself a big head start is using themes for your dinner nights. I walk around my kitchen to see what I need to buy and add it to a pickup grocery order. Then I make a note of where to find that recipe later whether I printed it off, saved it, etc. Next I look for recipes based on my template. LEVEL UP OPTION: Looking to save money? Use the Flipp app to shop deals in your area on meats. I fill in the template box with a general idea of what I am making Whether it be a leftovers night, a church night or traveling. I start by crossing out the nights I am not cooking. ^By the way, I will send you both templates! You don’t need to sign up for emails twice :) How I like to use it: Grab your free copy of this dinner template here when you join the BFC Email List! ( Or members can grab it right now here!) Did I save it to my collections on Bariatric Food Coach (members – you have this benefit!) or did I save it on Pinterest or email it to myself or rip it from a magazine? This row helps me find the recipe faster when it’s time. ![]() Recipe location – I often forget where I saved a recipe. Grilled chicken on Monday becomes Pico de Gallo Chicken. Recipe – I take the template and search for recipes here on the BFC recipe page. I take what the bot told me and plug it into the template row of my menu.Įxample: grilled chicken on Monday, pork chops on Tuesday, chili on Wednesday…etc… Template – I love using ChatGPT to get the ball rolling for me, but I prefer shopping with my eyes and looking at photos of recipes. This is currently the menu I am using in my household. I first created this template for my live session on using ChatGPT to Simplify Your Meal Planning. Leaning into your own style that considers your circumstances will pay dividends on eating foods that help you reach your health goes after bariatric surgery.įree menu template option #1: Weekly Dinners There is no wrong answer when it comes to getting a good meal on the table. Are you the only one eating or are you cooking for a family that “doesn’t have to eat bariatric meals?”Īre you a detailed person that likes a color coded menu plan? Or are you more of a scribble on a post-it note kind of planner? ![]() Several factors will impact your best style and strategy for meal planning. (In fact, I wrote a whole blog series about finding your meal planning style!) ![]() Free Meal Planning Templates for Bariatric PatientsĪround here I talk a LOT about meal planning that fits your style. ![]() ![]() A commonly used sound absorber is the underlay in carpet this works to draw energy from the sound wave and convert it into a tiny amount of heat, creating that ‘deadening’ of a sound. This method is very effective for high to medium frequencies, as the vibration strength is less than that of a low frequency sound, and therefore easier to disperse.Ībsorption performance varies a lot based on the frequency of sound and the absorptive capabilities of the material. Think about how much of a difference carpet or a wall rug can make in a brick or concrete room. Reflective barriers are a good way to block out exterior noise.ĭiffusion is a great way to prevent echoes, dispersing the sound wave in all directions when it hits an irregular surface. If you can always control the way sound is reflected then this type of soundproofing can be effective. Reflection is often used to redirect noise from outside - consider highway barriers, which reflect traffic noise into the sky. The most effective method is by creating a vacuum seal all around the room, but obviously this isn't an affordable or practical option in most homes. The answer to this largely depends on the type of sound you're trying to block out - or keep in. How well a material absorbs sound depends on a number of different factors, including material density and how porous it is.Īdvertisement Which is the most effective method of soundproofing? This is the kind of sound insulation provided by things like foam and rubber. When a sound wave hit a particular surface, the kinetic energy driving it is converted into a small amount of heat energy which dissipates, leeching power from the sound wave and causing it to decaying faster. This divides the energy of the wave, sending it in many different directions which depletes its energy faster. Diffusion When a sound wave hits an irregular surface like foam or carpet, the vibration breaks up and travels along many much smaller paths.The sound bouncing back off the surface creates an echo. Because the sound wave can't penetrate very far into the surface, the wave is turned back on itself like a ricochet. This usually occurs on flat, rigid surfaces with a lot of mass like concrete or brick walls. Reflection Sound is bounced off a surface.Below is a brief explanation of what happens in each case. Each of these reactions will depend entirely on the nature and composition of the material it comes into contact with, and each can be used to some extent in soundproofing. What are reflection, diffusion and absorption of sound?Ī sound wave can be controlled in one of three different ways – it can be reflected, diffused or absorbed. Deeper sounds like bass from a stereo are low frequency, higher sounds such as speech are around the mid to high level frequency range. The frequency of the sound wave, without getting technical, is the measure of how high or low the sound appears to the listener. This is why in space, no-one can hear you scream! Any given material will pass on a small amount of the wave to some extent, and the greater the distance it is passed, the less noisy the sound is on the other side of the material. Sound works by compressing and vibrating matter, and in a vacuum there's nothing to compress or vibrate. The most effective method of stopping sound from travelling is by putting some kind of vacuum in its path. A sound will vibrate the particles in a material, whether it is a gas, liquid or solid, losing a little bit of kinetic energy with each further movement. Sound travels as a longitudinal wave - a wave that causes air to compress and expand in the same direction as it travels. ![]() ![]() When sound hits a solid surface, it can either be reflected, diffused or absorbed. ![]() ![]() ![]() HQ461 was identified through phenotype-based high-throughput small-molecule screening and found to possess potent cytotoxicity. In this study, we report the discovery and the mechanism of action of a new molecular glue HQ461. However, the rarity of molecular glues has limited their potential as a general strategy for drug development. For example, the compactness of the thalidomide scaffold allowed the development of bivalent proteolysis targeting chimeras to direct cereblon to degrade disease-relevant proteins ( Lu et al., 2015 Winter et al., 2015). Third, molecular glues possess favorable pharmacological properties to serve as drug candidates. Second, molecular glues can target transcription factors and splicing factors, by recognizing either relatively flat surfaces or disordered regions of these proteins ( Han et al., 2017 Krönke et al., 2014 Lu et al., 2014 Tan et al., 2007). Such unique binding characteristics can be explained by induced protein-protein interactions and pre-existing protein surface complementarity as revealed by structural analysis of molecular glue-bound protein complexes ( Bussiere et al., 2020 Du et al., 2019 Faust et al., 2020 Tan et al., 2007). First, molecular glues often bind to their target proteins with modest or even undetectable affinities, while enhanced affinities are usually observed once a regulatory protein is also present in the system ( Bussiere et al., 2020 Du et al., 2019 Faust et al., 2020). Several common themes have emerged from this limited set of molecular glues. More recently, indisulam and related anticancer sulfonamides were discovered to function by promoting the interaction between the splicing factor RBM39 and the E3 ubiquitin ligase DCAF15, resulting in the degradation of RBM39 to cause aberrant pre-mRNA splicing ( Han et al., 2017 Uehara et al., 2017). Similarly, the thalidomide class of immunomodulatory drugs binds to the E3 ubiquitin ligase cereblon and alters its substrate specificity to recognize and degrade several zinc finger transcription factors ( Ito et al., 2010 Krönke et al., 2014 Lu et al., 2014). For example, macrocyclic natural products cyclosporin A, FK506, and rapamycin recruit FKBP proteins to the phosphatase calcineurin or the kinase mTORC1, interfering with their enzymatic activities to control intracellular signal transduction ( Brown et al., 1994 Liu et al., 1991 Sabatini et al., 1994). Notwithstanding, molecular glues are rare and were discovered serendipitously only a handful of molecular glues have been documented over the past four decades. As a result, molecular glues have been viewed enthusiastically as a unique pharmacological modality to target proteins without druggable pockets ( Maniaci and Ciulli, 2019). Unlike conventional small molecules that bind to active sites or allosteric sites to modulate the activity of their target proteins, molecular glues influence the activity or fate of their target proteins by bringing them to the vicinity of regulatory proteins. The name ‘molecular glue’ was first coined to describe the mechanism of action of the plant hormone auxin, which bridges an interaction between the E3 ubiquitin ligase TIR1 and IAA transcription repressors, leading to IAA destruction by the ubiquitin-proteasome system to activate auxin-response gene expression ( Tan et al., 2007). Molecular glues are a class of small molecules that induce the formation of protein-protein interactions to elicit biologic or therapeutic effects. Our studies reveal a new molecular glue that recruits its target protein directly to DDB1 to bypass the requirement of a substrate-specific receptor, presenting a new strategy for targeted protein degradation. Structure-activity relationship analysis of HQ461 revealed the importance of a 5-methylthiazol-2-amine pharmacophore and resulted in an HQ461 derivate with improved potency. ![]() Degradation of CCNK mediated by HQ461 compromised CDK12 function, leading to reduced phosphorylation of a CDK12 substrate, downregulation of DNA damage response genes, and cell death. Using loss-of-function and gain-of-function genetic screening in human cancer cells followed by biochemical reconstitution, we show that HQ461 acts by promoting an interaction between CDK12 and DDB1-CUL4-RBX1 E3 ubiquitin ligase, leading to polyubiquitination and degradation of CDK12-interacting protein Cyclin K (CCNK). Here, we report a new molecular glue HQ461 discovered by high-throughput screening. Molecular-glue degraders mediate interactions between target proteins and components of the ubiquitin-proteasome system to cause selective protein degradation. ![]() ![]() He's a retired judge who then was a deputy attorney general and once was a neighbor to Biden and remains friendly. The truck driver did not," Jerome Herlihy told me. For whatever reason, Neilia Biden, who was holding the baby, ended up in the right of way of Dunn's truck coming down a long hill. The accident was an accident, and though the police file no longer exists, coverage in the newspapers at the time made it clear that fault was not in question. Dunn of Pennsylvania, was not charged with drunk driving. Based on evidence and witness accounts, it appeared that Neilia Biden had pulled into the truck driver's right of way at an intersection with a two-way stop, and the tractor-trailer driver was unable to stop in time to avoid striking her vehicle: skid marks.īut as Politico noted in a 2009 profile of Biden, the other driver was not charged with drunken driving, or anything else that would indicate fault on his part. Whether Curtis Dunn was speeding is unknown, but he had applied his brakes, which was apparent from twin 150 ft. The speed limit on Limestone Road, at the intersection, was 35mph and huge REDUCE SPEED signs were posted a half-mile in both directions. Truckers traveling in either direction used the momentum coming down one hill, in order to climb the other. The intersection with Valley Road was extremely dangerous, located at the bottom of two steep hills. Limestone Road was a popular trucker shortcut in the Piedmont foothills leading from Delaware into Pennsylvania. At the time, it was a remote, rural section of New Castle County, described as follows by a probationary volunteer fireman who responded to the scene and attended the driver of the tractor-trailer: The accident took place at the intersection of Limestone and Valley Road in Hockessin, Delaware. A tractor-trailer, a guy who allegedly - and I never pursued it - drank his lunch instead of eating his lunch, broadsided my family and killed my wife instantly, and killed my daughter instantly, and hospitalized my two sons, with what were thought to be at the time permanent, fundamental injuries." 18 of that year, my wife and three kids were Christmas shopping for a Christmas tree. "I got elected when I was 29, and I got elected November the 7th. Biden told the crowd at the University of Iowa. It was an errant driver who stopped to drink instead of drive and hit a tractor-trailer, hit my children and my wife and killed them.Īnd in December 2007, while stumping for the Democratic presidential nomination in Iowa City, Biden said the following while answering a voter's question about negative campaigning: But, I say it here because it's so important for you to understand. I got a phone call saying, "Your wife's dead your daughter's dead." And I've only said that three times in public before. in a different circumstance, I got one of those phone calls. ![]() ![]() ![]() And, those of you who think it's presumptuous of me to say that. To the loved ones of the victims, there is nothing really we can say to erase this tragedy. During a speech he gave at the University of Delaware a week after the 9/11 terror attacks, for example, Biden said: It is true that at least twice, Biden has publicly stated or alleged that the driver tractor-trailer who hit his wife's station wagon had been drinking. Social media posts circulated during Joe Biden's 2020 presidential run declared that Biden had misrepresented the accident as being the fault of a drunken driver, and even that Biden had deliberately lied about it: For the ensuing 36 years of his Senate career, Biden famously commuted via Amtrak to Washington, D.C., from the family home in Wilmington, Delaware, daily in order to be home for his sons Beau and Hunter, who had been severely injured but survived the crash that killed their mother and sister.Īs in any such tragedy, one of the paramount questions is: what caused the fatal accident? Neilia Biden's station wagon was broadsided by a tractor-trailer truck at an intersection, but who - or what - was the underlying cause of the accident? Six weeks later, however, before he had assumed office, Biden's life took the most tragic of turns when his wife Neilia and their 1-year-old daughter, Naomi, were killed in an automobile accident. The seminal moment in the career of Joe Biden occurred in November 1972 when, as a 29-year-old lawyer whose only previous political experience was as a member of the New Castle County Council in Delaware, he pulled off an astounding upset victory over a Republican incumbent and won election to the U.S. No definitive evidence exists to prove or rule out whether the other driver had been drinking, and belief that drinking had contributed to the crash was reportedly prevalent among the local community and not something Biden simply made up on his own. ![]() ![]() ![]() Theoretically, it is even possible to make fudge in the microwave. The two ingredients go into a saucepan, where they can melt into a homogeneous mass for a few minutes. I don't remember where I got this "recipe" from, as I've been making it this way for years. The foundation for this quick fudge is sweetened condensed milk and chocolate or chocolate coating. Such a thing can't happen to you with this recipe: The homemade fudge is sure to succeed. On the other hand, sometimes the fudge is too soft. If you don't have a sugar thermometer or do something wrong, you get crumbly, hard, or bitter confectionery. The difficulty in classic recipes is that the basic mixture of sugar, butter, and cream must first be brought to a specific temperature and simmered for up to an hour at precisely X degrees while stirring. A small note: My vanilla fudge is not the original with caramel flavoring but a particularly quick and simple alternative. Not surprising since it's primarily made of sugar. Jump to:įudge, the melt-in-your-mouth caramel confection, is wonderfully sweet and creamy. And, of course, also good for self-indulgence in stressful times. On the contrary! With the right recipe - THIS recipe - you actually only need three ingredients and 5 minutes! The quick fudge is, therefore, a perfect last-minute-gift from the kitchen. Making vanilla fudge yourself is no art at all.
![]() ![]() I dunno, moderate the threads to separate the wheat for the chaff? How do you determine if a project s "real" or not? I mean, this is a problem that I imagine is going to snowball over time. So, technically, my project is more real than theirs.Īll joking aside though - now that we officially now have pre-kickstarter kickstarter threads, is there ever any intention to sort of. In fact, I'm just waiting for my Amazon payment setup to finish to launch my kickstarter. ![]() In fact, I've already got a prototype to show. Ouze wrote: How dare you impugn my motives, sir? I'll have you know I have every intention of following through with my project. I'll get some more photos up after dinner. These things are so damn cool with their little pointy teeth and Dracula style haircuts.Īnd, because Ouze is such a top-notch bloke, he even threw in a extra Ol' Ironbutt because the orders were late getting out. The butts come made in a flesh toned resin. Here's a group shot of them still in the packaging.Ī shot of FAB-1. There's a bit of flash on some of the wings to clean up but that won't be a problem.Īnd can I just say, a better set of rear ends I've never seen! As far as casting goes, they look excellent. I've never dealt with resin before so this should be interesting. I've been hanging to get my hands on these ever since the KS ended. Contained my brand spanking new Flying Assault Butts, made by Dakka's very own Ouze. So anyway, I got a little parcel in the mail this morning. Yeah the title grabbed you didn't it? You see a title like that and you just can't help yourself. ![]() ![]() ![]() The Redeem codes contain 12-digit alphanumeric codes entered into Fortnite Website or Application. The items that can be redeemed include various things such as – Skins, Emotes, Virtual Currency like – V-bucks, etc. US School Holidays 2023 Active Fortnite Redeem Codes September2023įortnite Redeem Codes are unique codes used to redeem exclusive in-game items. Garena Free Fire Max Redeem Code Today Trending The users who redeem all five cosmetic items can unlock an additional outfit, which will be granted in-game. In the redeem code, there is a specific period for the users to perform the task, and after the expiry of that period, they will not get any reward or other various benefits. The new users can download the Fortnite Game for their Android Devices and their PC from the official website. ![]() The company decides the Rewards, which are given to users who use the redeem code before the expiry date. ![]() In the beginning, Fortnite Game was available on the Google Play Store, but due to some policy violations and other breach of contract issues, Google Play Store has removed it from their platform. The drawback of Fortnite Game is that it is still not available on the Google Play Store, so users can download it on any smart gadget. 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